SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

The onset of mammalian puberty is sensitive to metabolic changes and nutritional status, but the mechanisms underlying this phenomenon are poorly understood. Here the authors show that the epigenetic regulator of transcription, SIRT1, mediates the effects of under and overnutrition on pubertal timin...

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Main Authors: M. J. Vazquez, C. A. Toro, J. M. Castellano, F. Ruiz-Pino, J. Roa, D. Beiroa, V. Heras, I. Velasco, C. Dieguez, L. Pinilla, F. Gaytan, R. Nogueiras, M. A. Bosch, O. K. Rønnekleiv, A. Lomniczi, S. R. Ojeda, M. Tena-Sempere
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/71c4e883f27d431aa22490145fc7c289
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https://doaj.org/article/71c4e883f27d431aa22490145fc7c289

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