SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

The onset of mammalian puberty is sensitive to metabolic changes and nutritional status, but the mechanisms underlying this phenomenon are poorly understood. Here the authors show that the epigenetic regulator of transcription, SIRT1, mediates the effects of under and overnutrition on pubertal timin...

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Autores principales:	M. J. Vazquez, C. A. Toro, J. M. Castellano, F. Ruiz-Pino, J. Roa, D. Beiroa, V. Heras, I. Velasco, C. Dieguez, L. Pinilla, F. Gaytan, R. Nogueiras, M. A. Bosch, O. K. Rønnekleiv, A. Lomniczi, S. R. Ojeda, M. Tena-Sempere
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71c4e883f27d431aa22490145fc7c289
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spelling	oai:doaj.org-article:71c4e883f27d431aa22490145fc7c2892021-12-02T14:40:03ZSIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression10.1038/s41467-018-06459-92041-1723https://doaj.org/article/71c4e883f27d431aa22490145fc7c2892018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06459-9https://doaj.org/toc/2041-1723The onset of mammalian puberty is sensitive to metabolic changes and nutritional status, but the mechanisms underlying this phenomenon are poorly understood. Here the authors show that the epigenetic regulator of transcription, SIRT1, mediates the effects of under and overnutrition on pubertal timing by controlling the expression of Kiss1 in hypothalamic neurons.M. J. VazquezC. A. ToroJ. M. CastellanoF. Ruiz-PinoJ. RoaD. BeiroaV. HerasI. VelascoC. DieguezL. PinillaF. GaytanR. NogueirasM. A. BoschO. K. RønnekleivA. LomnicziS. R. OjedaM. Tena-SempereNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. J. Vazquez C. A. Toro J. M. Castellano F. Ruiz-Pino J. Roa D. Beiroa V. Heras I. Velasco C. Dieguez L. Pinilla F. Gaytan R. Nogueiras M. A. Bosch O. K. Rønnekleiv A. Lomniczi S. R. Ojeda M. Tena-Sempere SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
description	The onset of mammalian puberty is sensitive to metabolic changes and nutritional status, but the mechanisms underlying this phenomenon are poorly understood. Here the authors show that the epigenetic regulator of transcription, SIRT1, mediates the effects of under and overnutrition on pubertal timing by controlling the expression of Kiss1 in hypothalamic neurons.
format	article
author	M. J. Vazquez C. A. Toro J. M. Castellano F. Ruiz-Pino J. Roa D. Beiroa V. Heras I. Velasco C. Dieguez L. Pinilla F. Gaytan R. Nogueiras M. A. Bosch O. K. Rønnekleiv A. Lomniczi S. R. Ojeda M. Tena-Sempere
author_facet	M. J. Vazquez C. A. Toro J. M. Castellano F. Ruiz-Pino J. Roa D. Beiroa V. Heras I. Velasco C. Dieguez L. Pinilla F. Gaytan R. Nogueiras M. A. Bosch O. K. Rønnekleiv A. Lomniczi S. R. Ojeda M. Tena-Sempere
author_sort	M. J. Vazquez
title	SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
title_short	SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
title_full	SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
title_fullStr	SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
title_full_unstemmed	SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
title_sort	sirt1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling kiss1 expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/71c4e883f27d431aa22490145fc7c289
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SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

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