Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR

Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR

The IL-6 family cytokine Oncostatin M (OSM) is involved in cell development, growth, hematopoiesis, inflammation, and cancer. Intriguingly, OSM has proliferative and antiproliferative effects depending on the target cell. The molecular mechanisms underlying these opposing effects are not fully under...

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Bibliographic Details
Main Authors: Lena Jakob, Tony Andreas Müller, Michael Rassner, Helen Kleinfelder, Pia Veratti, Jan Mitschke, Cornelius Miething, Robert A. J. Oostendorp, Dietmar Pfeifer, Miguel Waterhouse, Justus Duyster
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
mOSM
proliferation
JAK-STAT
OSMR
LIFR
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/71c64d0264c8412aa6e6d7b528cfde00
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https://doaj.org/article/71c64d0264c8412aa6e6d7b528cfde00

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