Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.

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Bibliographic Details
Main Authors: Hajime Abe, Norihiko Takeda, Takayuki Isagawa, Hiroaki Semba, Satoshi Nishimura, Masaki Suimye Morioka, Yu Nakagama, Tatsuyuki Sato, Katsura Soma, Katsuhiro Koyama, Masaki Wake, Manami Katoh, Masataka Asagiri, Michael L. Neugent, Jung-whan Kim, Christian Stockmann, Tomo Yonezawa, Ryo Inuzuka, Yasushi Hirota, Koji Maemura, Takeshi Yamashita, Kinya Otsu, Ichiro Manabe, Ryozo Nagai, Issei Komuro
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/71dda70f0fa943e6abde76eae9ef37b9
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