NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region

The mechanisms underlying specific TSS selection in mammals remain unclear. Here the authors show that the ubiquitously expressed transcription factor NF-Y regulate fidelity of transcription initiation at gene promoters, maintaining the region upstream of TSSs in a nucleosome-depleted state, while p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrew J. Oldfield, Telmo Henriques, Dhirendra Kumar, Adam B. Burkholder, Senthilkumar Cinghu, Damien Paulet, Brian D. Bennett, Pengyi Yang, Benjamin S. Scruggs, Christopher A. Lavender, Eric Rivals, Karen Adelman, Raja Jothi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71e2bfa890304bdaa5931f07b5e2e8a9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:71e2bfa890304bdaa5931f07b5e2e8a9
record_format	dspace
spelling	oai:doaj.org-article:71e2bfa890304bdaa5931f07b5e2e8a92021-12-02T15:36:18ZNF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region10.1038/s41467-019-10905-72041-1723https://doaj.org/article/71e2bfa890304bdaa5931f07b5e2e8a92019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10905-7https://doaj.org/toc/2041-1723The mechanisms underlying specific TSS selection in mammals remain unclear. Here the authors show that the ubiquitously expressed transcription factor NF-Y regulate fidelity of transcription initiation at gene promoters, maintaining the region upstream of TSSs in a nucleosome-depleted state, while protecting this region from ectopic transcription initiation.Andrew J. OldfieldTelmo HenriquesDhirendra KumarAdam B. BurkholderSenthilkumar CinghuDamien PauletBrian D. BennettPengyi YangBenjamin S. ScruggsChristopher A. LavenderEric RivalsKaren AdelmanRaja JothiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew J. Oldfield Telmo Henriques Dhirendra Kumar Adam B. Burkholder Senthilkumar Cinghu Damien Paulet Brian D. Bennett Pengyi Yang Benjamin S. Scruggs Christopher A. Lavender Eric Rivals Karen Adelman Raja Jothi NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
description	The mechanisms underlying specific TSS selection in mammals remain unclear. Here the authors show that the ubiquitously expressed transcription factor NF-Y regulate fidelity of transcription initiation at gene promoters, maintaining the region upstream of TSSs in a nucleosome-depleted state, while protecting this region from ectopic transcription initiation.
format	article
author	Andrew J. Oldfield Telmo Henriques Dhirendra Kumar Adam B. Burkholder Senthilkumar Cinghu Damien Paulet Brian D. Bennett Pengyi Yang Benjamin S. Scruggs Christopher A. Lavender Eric Rivals Karen Adelman Raja Jothi
author_facet	Andrew J. Oldfield Telmo Henriques Dhirendra Kumar Adam B. Burkholder Senthilkumar Cinghu Damien Paulet Brian D. Bennett Pengyi Yang Benjamin S. Scruggs Christopher A. Lavender Eric Rivals Karen Adelman Raja Jothi
author_sort	Andrew J. Oldfield
title	NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
title_short	NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
title_full	NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
title_fullStr	NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
title_full_unstemmed	NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
title_sort	nf-y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/71e2bfa890304bdaa5931f07b5e2e8a9
work_keys_str_mv	AT andrewjoldfield nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT telmohenriques nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT dhirendrakumar nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT adambburkholder nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT senthilkumarcinghu nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT damienpaulet nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT briandbennett nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT pengyiyang nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT benjaminsscruggs nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT christopheralavender nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT ericrivals nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT karenadelman nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion AT rajajothi nfycontrolsfidelityoftranscriptioninitiationatgenepromotersthroughmaintenanceofthenucleosomedepletedregion
_version_	1718386359326998528

NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region

Ejemplares similares