Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.

Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.

Yeast DNA polymerase ε (Pol ε) is a highly accurate and processive enzyme that participates in nuclear DNA replication of the leading strand template. In addition to a large subunit (Pol2) harboring the polymerase and proofreading exonuclease active sites, Pol ε also has one essential subunit (Dpb2)...

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Bibliographic Details
Main Authors: Anna Aksenova, Kirill Volkov, Jaroslaw Maceluch, Zachary F Pursell, Igor B Rogozin, Thomas A Kunkel, Youri I Pavlov, Erik Johansson
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Genetics
QH426-470
Online Access:https://doaj.org/article/71e5bfc8f21d485e8204bf7838102d4d
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