Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affect...
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Nature Portfolio
2017
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oai:doaj.org-article:71f6e3ed3cbf4216a67afc3e8eda8b112021-12-02T15:38:53ZGenome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity10.1038/s41467-017-00934-52041-1723https://doaj.org/article/71f6e3ed3cbf4216a67afc3e8eda8b112017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00934-5https://doaj.org/toc/2041-1723Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan.Peter K. JoshiNicola PirastuKatherine A. KentistouKrista FischerEdith HoferKatharina E. SchrautDavid W. ClarkTeresa NutileCatriona L. K. BarnesPaul R. H. J. TimmersXia ShenIlaria GandinAaron F. McDaidThomas Folkmann HansenScott D. GordonFranco GiulianiniThibaud S. BoutinAbdel AbdellaouiWei ZhaoCarolina Medina-GomezTraci M. BartzStella TrompetLeslie A. LangeLaura RaffieldAshley van der SpekTessel E. GaleslootPetroula ProitsiLisa R. YanekLawrence F. BielakAntony PaytonFederico MurgiaMaria Pina ConcasGinevra BiinoSalman M. TajuddinIlkka SeppäläNajaf AminEric BoerwinkleAnders D. BørglumArchie CampbellEllen W. DemerathIlja DemuthJessica D. FaulIan FordAlessandro GialluisiMartin GögeleMariaElisa GraffAroon HingoraniJouke-Jan HottengaDavid M. HougaardMikko A. HurmeM. Arfan IkramMarja JylhäDiana KuhLannie LigthartChristina M. LillUlman LindenbergerThomas LumleyReedik MägiPedro Marques-VidalSarah E. MedlandLili MilaniReka NagyWilliam E. R. OllierPatricia A. PeyserPeter P. PramstallerPaul M. RidkerFernando RivadeneiraDaniela RuggieroYasaman SabaReinhold SchmidtHelena SchmidtP. Eline SlagboomBlair H. SmithJennifer A. SmithNona SotoodehniaElisabeth Steinhagen-ThiessenFrank J. A. van RooijAndré L. VerbeekSita H. VermeulenPeter VollenweiderYunpeng WangThomas WergeJohn B. WhitfieldAlan B. ZondermanTerho LehtimäkiMichele K. EvansMario PirastuChristian FuchsbergerLars BertramNeil PendletonSharon L. R. KardiaMarina CiulloDiane M. BeckerAndrew WongBruce M. PsatyCornelia M. van DuijnJames G. WilsonJ. Wouter JukemaLambertus KiemeneyAndré G. UitterlindenNora FranceschiniKari E. NorthDavid R. WeirAndres MetspaluDorret I. BoomsmaCaroline HaywardDaniel ChasmanNicholas G. MartinNaveed SattarHarry CampbellTōnu EskoZoltán KutalikJames F. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
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Science Q Peter K. Joshi Nicola Pirastu Katherine A. Kentistou Krista Fischer Edith Hofer Katharina E. Schraut David W. Clark Teresa Nutile Catriona L. K. Barnes Paul R. H. J. Timmers Xia Shen Ilaria Gandin Aaron F. McDaid Thomas Folkmann Hansen Scott D. Gordon Franco Giulianini Thibaud S. Boutin Abdel Abdellaoui Wei Zhao Carolina Medina-Gomez Traci M. Bartz Stella Trompet Leslie A. Lange Laura Raffield Ashley van der Spek Tessel E. Galesloot Petroula Proitsi Lisa R. Yanek Lawrence F. Bielak Antony Payton Federico Murgia Maria Pina Concas Ginevra Biino Salman M. Tajuddin Ilkka Seppälä Najaf Amin Eric Boerwinkle Anders D. Børglum Archie Campbell Ellen W. Demerath Ilja Demuth Jessica D. Faul Ian Ford Alessandro Gialluisi Martin Gögele MariaElisa Graff Aroon Hingorani Jouke-Jan Hottenga David M. Hougaard Mikko A. Hurme M. Arfan Ikram Marja Jylhä Diana Kuh Lannie Ligthart Christina M. Lill Ulman Lindenberger Thomas Lumley Reedik Mägi Pedro Marques-Vidal Sarah E. Medland Lili Milani Reka Nagy William E. R. Ollier Patricia A. Peyser Peter P. Pramstaller Paul M. Ridker Fernando Rivadeneira Daniela Ruggiero Yasaman Saba Reinhold Schmidt Helena Schmidt P. Eline Slagboom Blair H. Smith Jennifer A. Smith Nona Sotoodehnia Elisabeth Steinhagen-Thiessen Frank J. A. van Rooij André L. Verbeek Sita H. Vermeulen Peter Vollenweider Yunpeng Wang Thomas Werge John B. Whitfield Alan B. Zonderman Terho Lehtimäki Michele K. Evans Mario Pirastu Christian Fuchsberger Lars Bertram Neil Pendleton Sharon L. R. Kardia Marina Ciullo Diane M. Becker Andrew Wong Bruce M. Psaty Cornelia M. van Duijn James G. Wilson J. Wouter Jukema Lambertus Kiemeney André G. Uitterlinden Nora Franceschini Kari E. North David R. Weir Andres Metspalu Dorret I. Boomsma Caroline Hayward Daniel Chasman Nicholas G. Martin Naveed Sattar Harry Campbell Tōnu Esko Zoltán Kutalik James F. Wilson Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| description |
Variability in human longevity is genetically influenced. Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan. |
| format |
article |
| author |
Peter K. Joshi Nicola Pirastu Katherine A. Kentistou Krista Fischer Edith Hofer Katharina E. Schraut David W. Clark Teresa Nutile Catriona L. K. Barnes Paul R. H. J. Timmers Xia Shen Ilaria Gandin Aaron F. McDaid Thomas Folkmann Hansen Scott D. Gordon Franco Giulianini Thibaud S. Boutin Abdel Abdellaoui Wei Zhao Carolina Medina-Gomez Traci M. Bartz Stella Trompet Leslie A. Lange Laura Raffield Ashley van der Spek Tessel E. Galesloot Petroula Proitsi Lisa R. Yanek Lawrence F. Bielak Antony Payton Federico Murgia Maria Pina Concas Ginevra Biino Salman M. Tajuddin Ilkka Seppälä Najaf Amin Eric Boerwinkle Anders D. Børglum Archie Campbell Ellen W. Demerath Ilja Demuth Jessica D. Faul Ian Ford Alessandro Gialluisi Martin Gögele MariaElisa Graff Aroon Hingorani Jouke-Jan Hottenga David M. Hougaard Mikko A. Hurme M. Arfan Ikram Marja Jylhä Diana Kuh Lannie Ligthart Christina M. Lill Ulman Lindenberger Thomas Lumley Reedik Mägi Pedro Marques-Vidal Sarah E. Medland Lili Milani Reka Nagy William E. R. Ollier Patricia A. Peyser Peter P. Pramstaller Paul M. Ridker Fernando Rivadeneira Daniela Ruggiero Yasaman Saba Reinhold Schmidt Helena Schmidt P. Eline Slagboom Blair H. Smith Jennifer A. Smith Nona Sotoodehnia Elisabeth Steinhagen-Thiessen Frank J. A. van Rooij André L. Verbeek Sita H. Vermeulen Peter Vollenweider Yunpeng Wang Thomas Werge John B. Whitfield Alan B. Zonderman Terho Lehtimäki Michele K. Evans Mario Pirastu Christian Fuchsberger Lars Bertram Neil Pendleton Sharon L. R. Kardia Marina Ciullo Diane M. Becker Andrew Wong Bruce M. Psaty Cornelia M. van Duijn James G. Wilson J. Wouter Jukema Lambertus Kiemeney André G. Uitterlinden Nora Franceschini Kari E. North David R. Weir Andres Metspalu Dorret I. Boomsma Caroline Hayward Daniel Chasman Nicholas G. Martin Naveed Sattar Harry Campbell Tōnu Esko Zoltán Kutalik James F. Wilson |
| author_facet |
Peter K. Joshi Nicola Pirastu Katherine A. Kentistou Krista Fischer Edith Hofer Katharina E. Schraut David W. Clark Teresa Nutile Catriona L. K. Barnes Paul R. H. J. Timmers Xia Shen Ilaria Gandin Aaron F. McDaid Thomas Folkmann Hansen Scott D. Gordon Franco Giulianini Thibaud S. Boutin Abdel Abdellaoui Wei Zhao Carolina Medina-Gomez Traci M. Bartz Stella Trompet Leslie A. Lange Laura Raffield Ashley van der Spek Tessel E. Galesloot Petroula Proitsi Lisa R. Yanek Lawrence F. Bielak Antony Payton Federico Murgia Maria Pina Concas Ginevra Biino Salman M. Tajuddin Ilkka Seppälä Najaf Amin Eric Boerwinkle Anders D. Børglum Archie Campbell Ellen W. Demerath Ilja Demuth Jessica D. Faul Ian Ford Alessandro Gialluisi Martin Gögele MariaElisa Graff Aroon Hingorani Jouke-Jan Hottenga David M. Hougaard Mikko A. Hurme M. Arfan Ikram Marja Jylhä Diana Kuh Lannie Ligthart Christina M. Lill Ulman Lindenberger Thomas Lumley Reedik Mägi Pedro Marques-Vidal Sarah E. Medland Lili Milani Reka Nagy William E. R. Ollier Patricia A. Peyser Peter P. Pramstaller Paul M. Ridker Fernando Rivadeneira Daniela Ruggiero Yasaman Saba Reinhold Schmidt Helena Schmidt P. Eline Slagboom Blair H. Smith Jennifer A. Smith Nona Sotoodehnia Elisabeth Steinhagen-Thiessen Frank J. A. van Rooij André L. Verbeek Sita H. Vermeulen Peter Vollenweider Yunpeng Wang Thomas Werge John B. Whitfield Alan B. Zonderman Terho Lehtimäki Michele K. Evans Mario Pirastu Christian Fuchsberger Lars Bertram Neil Pendleton Sharon L. R. Kardia Marina Ciullo Diane M. Becker Andrew Wong Bruce M. Psaty Cornelia M. van Duijn James G. Wilson J. Wouter Jukema Lambertus Kiemeney André G. Uitterlinden Nora Franceschini Kari E. North David R. Weir Andres Metspalu Dorret I. Boomsma Caroline Hayward Daniel Chasman Nicholas G. Martin Naveed Sattar Harry Campbell Tōnu Esko Zoltán Kutalik James F. Wilson |
| author_sort |
Peter K. Joshi |
| title |
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_short |
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_full |
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_fullStr |
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_full_unstemmed |
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_sort |
genome-wide meta-analysis associates hla-dqa1/drb1 and lpa and lifestyle factors with human longevity |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/71f6e3ed3cbf4216a67afc3e8eda8b11 |
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