Degradation of insulin amyloid by antibiotic minocycline and formation of toxic intermediates

Abstract Insulin balls, localized insulin amyloids formed at subcutaneous insulin-injection sites in patients with diabetes, cause poor glycemic control owing to impairments in insulin absorption. Our previous study has shown that some insulin balls are cytotoxic, but others are not, implying amyloi...

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Autores principales: Wakako Mori, Keisuke Yuzu, Nadine Lobsiger, Hideo Nishioka, Hisako Sato, Terumasa Nagase, Keiichi Iwaya, Mikael Lindgren, Tamotsu Zako
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7235113440674dfc9f570e47401314da
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