Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

The polycomb repressor protein Bmi1 has a role in self-renewal and tumorigenesis. Here, the authors use lineage tracing to show that Bmi-expressing cells are a distinct population of cells, primarily found in the luminal compartment, which is castration resistant, can initiate cancer and regenerate...

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Autores principales: Young A. Yoo, Meejeon Roh, Anum F. Naseem, Barbara Lysy, Mohamed M. Desouki, Kenji Unno, Sarki A. Abdulkadir
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/723bb9021c454c7c895f31deacc88d0a
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