Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

The polycomb repressor protein Bmi1 has a role in self-renewal and tumorigenesis. Here, the authors use lineage tracing to show that Bmi-expressing cells are a distinct population of cells, primarily found in the luminal compartment, which is castration resistant, can initiate cancer and regenerate...

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Autores principales:	Young A. Yoo, Meejeon Roh, Anum F. Naseem, Barbara Lysy, Mohamed M. Desouki, Kenji Unno, Sarki A. Abdulkadir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/723bb9021c454c7c895f31deacc88d0a
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spelling	oai:doaj.org-article:723bb9021c454c7c895f31deacc88d0a2021-12-02T15:34:31ZBmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation10.1038/ncomms129432041-1723https://doaj.org/article/723bb9021c454c7c895f31deacc88d0a2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12943https://doaj.org/toc/2041-1723The polycomb repressor protein Bmi1 has a role in self-renewal and tumorigenesis. Here, the authors use lineage tracing to show that Bmi-expressing cells are a distinct population of cells, primarily found in the luminal compartment, which is castration resistant, can initiate cancer and regenerate prostate.Young A. YooMeejeon RohAnum F. NaseemBarbara LysyMohamed M. DesoukiKenji UnnoSarki A. AbdulkadirNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Young A. Yoo Meejeon Roh Anum F. Naseem Barbara Lysy Mohamed M. Desouki Kenji Unno Sarki A. Abdulkadir Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
description	The polycomb repressor protein Bmi1 has a role in self-renewal and tumorigenesis. Here, the authors use lineage tracing to show that Bmi-expressing cells are a distinct population of cells, primarily found in the luminal compartment, which is castration resistant, can initiate cancer and regenerate prostate.
format	article
author	Young A. Yoo Meejeon Roh Anum F. Naseem Barbara Lysy Mohamed M. Desouki Kenji Unno Sarki A. Abdulkadir
author_facet	Young A. Yoo Meejeon Roh Anum F. Naseem Barbara Lysy Mohamed M. Desouki Kenji Unno Sarki A. Abdulkadir
author_sort	Young A. Yoo
title	Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
title_short	Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
title_full	Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
title_fullStr	Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
title_full_unstemmed	Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
title_sort	bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/723bb9021c454c7c895f31deacc88d0a
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Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

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