Combination of consensus and ensemble docking strategies for the discovery of human dihydroorotate dehydrogenase inhibitors

Abstract The inconsistencies in the performance of the virtual screening (VS) process, depending on the used software and structural conformation of the protein, is a challenging issue in the drug design and discovery field. Varying performance, especially in terms of early recognition of the potent...

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Auteurs principaux: Garri Chilingaryan, Narek Abelyan, Arsen Sargsyan, Karen Nazaryan, Andre Serobian, Hovakim Zakaryan
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/723fa34d85bd42ff9cba9172a8c7d336
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