Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

Evolutionary steering uses therapies to control tumour evolution by exploiting trade-offs. Here, using a barcoding approach applied to large cell populations, the authors explore evolutionary steering in lung cancer cells treated with EGFR inhibitors.

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Autores principales:	Ahmet Acar, Daniel Nichol, Javier Fernandez-Mateos, George D. Cresswell, Iros Barozzi, Sung Pil Hong, Nicholas Trahearn, Inmaculada Spiteri, Mark Stubbs, Rosemary Burke, Adam Stewart, Giulio Caravagna, Benjamin Werner, Georgios Vlachogiannis, Carlo C. Maley, Luca Magnani, Nicola Valeri, Udai Banerji, Andrea Sottoriva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7266ff52e4984f1da8cfe86c3ba11937
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:7266ff52e4984f1da8cfe86c3ba119372021-12-02T17:33:12ZExploiting evolutionary steering to induce collateral drug sensitivity in cancer10.1038/s41467-020-15596-z2041-1723https://doaj.org/article/7266ff52e4984f1da8cfe86c3ba119372020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15596-zhttps://doaj.org/toc/2041-1723Evolutionary steering uses therapies to control tumour evolution by exploiting trade-offs. Here, using a barcoding approach applied to large cell populations, the authors explore evolutionary steering in lung cancer cells treated with EGFR inhibitors.Ahmet AcarDaniel NicholJavier Fernandez-MateosGeorge D. CresswellIros BarozziSung Pil HongNicholas TrahearnInmaculada SpiteriMark StubbsRosemary BurkeAdam StewartGiulio CaravagnaBenjamin WernerGeorgios VlachogiannisCarlo C. MaleyLuca MagnaniNicola ValeriUdai BanerjiAndrea SottorivaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ahmet Acar Daniel Nichol Javier Fernandez-Mateos George D. Cresswell Iros Barozzi Sung Pil Hong Nicholas Trahearn Inmaculada Spiteri Mark Stubbs Rosemary Burke Adam Stewart Giulio Caravagna Benjamin Werner Georgios Vlachogiannis Carlo C. Maley Luca Magnani Nicola Valeri Udai Banerji Andrea Sottoriva Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
description	Evolutionary steering uses therapies to control tumour evolution by exploiting trade-offs. Here, using a barcoding approach applied to large cell populations, the authors explore evolutionary steering in lung cancer cells treated with EGFR inhibitors.
format	article
author	Ahmet Acar Daniel Nichol Javier Fernandez-Mateos George D. Cresswell Iros Barozzi Sung Pil Hong Nicholas Trahearn Inmaculada Spiteri Mark Stubbs Rosemary Burke Adam Stewart Giulio Caravagna Benjamin Werner Georgios Vlachogiannis Carlo C. Maley Luca Magnani Nicola Valeri Udai Banerji Andrea Sottoriva
author_facet	Ahmet Acar Daniel Nichol Javier Fernandez-Mateos George D. Cresswell Iros Barozzi Sung Pil Hong Nicholas Trahearn Inmaculada Spiteri Mark Stubbs Rosemary Burke Adam Stewart Giulio Caravagna Benjamin Werner Georgios Vlachogiannis Carlo C. Maley Luca Magnani Nicola Valeri Udai Banerji Andrea Sottoriva
author_sort	Ahmet Acar
title	Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
title_short	Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
title_full	Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
title_fullStr	Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
title_full_unstemmed	Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
title_sort	exploiting evolutionary steering to induce collateral drug sensitivity in cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7266ff52e4984f1da8cfe86c3ba11937
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Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

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