Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands

Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates onco...

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Autores principales: Florian Haller, Matthias Bieg, Rainer Will, Cindy Körner, Dieter Weichenhan, Alexander Bott, Naveed Ishaque, Pavlo Lutsik, Evgeny A. Moskalev, Sarina K. Mueller, Marion Bähr, Angelika Woerner, Birgit Kaiser, Claudia Scherl, Marlen Haderlein, Kortine Kleinheinz, Rainer Fietkau, Heinrich Iro, Roland Eils, Arndt Hartmann, Christoph Plass, Stefan Wiemann, Abbas Agaimy
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/727b2361a8284964b7ca75f696b31bab
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spelling oai:doaj.org-article:727b2361a8284964b7ca75f696b31bab2021-12-02T16:57:11ZEnhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands10.1038/s41467-018-08069-x2041-1723https://doaj.org/article/727b2361a8284964b7ca75f696b31bab2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08069-xhttps://doaj.org/toc/2041-1723Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3.Florian HallerMatthias BiegRainer WillCindy KörnerDieter WeichenhanAlexander BottNaveed IshaquePavlo LutsikEvgeny A. MoskalevSarina K. MuellerMarion BährAngelika WoernerBirgit KaiserClaudia ScherlMarlen HaderleinKortine KleinheinzRainer FietkauHeinrich IroRoland EilsArndt HartmannChristoph PlassStefan WiemannAbbas AgaimyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Florian Haller
Matthias Bieg
Rainer Will
Cindy Körner
Dieter Weichenhan
Alexander Bott
Naveed Ishaque
Pavlo Lutsik
Evgeny A. Moskalev
Sarina K. Mueller
Marion Bähr
Angelika Woerner
Birgit Kaiser
Claudia Scherl
Marlen Haderlein
Kortine Kleinheinz
Rainer Fietkau
Heinrich Iro
Roland Eils
Arndt Hartmann
Christoph Plass
Stefan Wiemann
Abbas Agaimy
Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
description Acinic cell carcinoma (AciCC) is a rare salivary gland carcinoma that is poorly understood. Here the authors perform genomic, transcriptomic and epigenomic profiling of AciCC and find highly recurrent and specific rearrangements [t(4;9)(q13;q31)], which lead to enhancer hijacking that activates oncogenic transcription factor NR4A3.
format article
author Florian Haller
Matthias Bieg
Rainer Will
Cindy Körner
Dieter Weichenhan
Alexander Bott
Naveed Ishaque
Pavlo Lutsik
Evgeny A. Moskalev
Sarina K. Mueller
Marion Bähr
Angelika Woerner
Birgit Kaiser
Claudia Scherl
Marlen Haderlein
Kortine Kleinheinz
Rainer Fietkau
Heinrich Iro
Roland Eils
Arndt Hartmann
Christoph Plass
Stefan Wiemann
Abbas Agaimy
author_facet Florian Haller
Matthias Bieg
Rainer Will
Cindy Körner
Dieter Weichenhan
Alexander Bott
Naveed Ishaque
Pavlo Lutsik
Evgeny A. Moskalev
Sarina K. Mueller
Marion Bähr
Angelika Woerner
Birgit Kaiser
Claudia Scherl
Marlen Haderlein
Kortine Kleinheinz
Rainer Fietkau
Heinrich Iro
Roland Eils
Arndt Hartmann
Christoph Plass
Stefan Wiemann
Abbas Agaimy
author_sort Florian Haller
title Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
title_short Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
title_full Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
title_fullStr Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
title_full_unstemmed Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
title_sort enhancer hijacking activates oncogenic transcription factor nr4a3 in acinic cell carcinomas of the salivary glands
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/727b2361a8284964b7ca75f696b31bab
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