Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

Lysosomal acidification defects have been implicated in various neurodegenerative disorders. Baghet al. show that the V0a1 subunit of v-ATPase requires palmitoylation for correct sorting and trafficking to the lysosome membrane, and that such a process is impaired in a mouse model of a devastating n...

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Autores principales: Maria B. Bagh, Shiyong Peng, Goutam Chandra, Zhongjian Zhang, Satya P. Singh, Nagarajan Pattabiraman, Aiyi Liu, Anil B. Mukherjee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/728ace11a95a4edda7a3da8550cb2ff6
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