Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

Lysosomal acidification defects have been implicated in various neurodegenerative disorders. Baghet al. show that the V0a1 subunit of v-ATPase requires palmitoylation for correct sorting and trafficking to the lysosome membrane, and that such a process is impaired in a mouse model of a devastating n...

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Autores principales:	Maria B. Bagh, Shiyong Peng, Goutam Chandra, Zhongjian Zhang, Satya P. Singh, Nagarajan Pattabiraman, Aiyi Liu, Anil B. Mukherjee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/728ace11a95a4edda7a3da8550cb2ff6
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spelling	oai:doaj.org-article:728ace11a95a4edda7a3da8550cb2ff62021-12-02T14:40:35ZMisrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model10.1038/ncomms146122041-1723https://doaj.org/article/728ace11a95a4edda7a3da8550cb2ff62017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14612https://doaj.org/toc/2041-1723Lysosomal acidification defects have been implicated in various neurodegenerative disorders. Baghet al. show that the V0a1 subunit of v-ATPase requires palmitoylation for correct sorting and trafficking to the lysosome membrane, and that such a process is impaired in a mouse model of a devastating neurodegenerative lysosomal storage disease, INCL.Maria B. BaghShiyong PengGoutam ChandraZhongjian ZhangSatya P. SinghNagarajan PattabiramanAiyi LiuAnil B. MukherjeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria B. Bagh Shiyong Peng Goutam Chandra Zhongjian Zhang Satya P. Singh Nagarajan Pattabiraman Aiyi Liu Anil B. Mukherjee Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
description	Lysosomal acidification defects have been implicated in various neurodegenerative disorders. Baghet al. show that the V0a1 subunit of v-ATPase requires palmitoylation for correct sorting and trafficking to the lysosome membrane, and that such a process is impaired in a mouse model of a devastating neurodegenerative lysosomal storage disease, INCL.
format	article
author	Maria B. Bagh Shiyong Peng Goutam Chandra Zhongjian Zhang Satya P. Singh Nagarajan Pattabiraman Aiyi Liu Anil B. Mukherjee
author_facet	Maria B. Bagh Shiyong Peng Goutam Chandra Zhongjian Zhang Satya P. Singh Nagarajan Pattabiraman Aiyi Liu Anil B. Mukherjee
author_sort	Maria B. Bagh
title	Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
title_short	Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
title_full	Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
title_fullStr	Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
title_full_unstemmed	Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
title_sort	misrouting of v-atpase subunit v0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/728ace11a95a4edda7a3da8550cb2ff6
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Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

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