Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
Lysosomal acidification defects have been implicated in various neurodegenerative disorders. Baghet al. show that the V0a1 subunit of v-ATPase requires palmitoylation for correct sorting and trafficking to the lysosome membrane, and that such a process is impaired in a mouse model of a devastating n...
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Nature Portfolio
2017
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oai:doaj.org-article:728ace11a95a4edda7a3da8550cb2ff62021-12-02T14:40:35ZMisrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model10.1038/ncomms146122041-1723https://doaj.org/article/728ace11a95a4edda7a3da8550cb2ff62017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14612https://doaj.org/toc/2041-1723Lysosomal acidification defects have been implicated in various neurodegenerative disorders. Baghet al. show that the V0a1 subunit of v-ATPase requires palmitoylation for correct sorting and trafficking to the lysosome membrane, and that such a process is impaired in a mouse model of a devastating neurodegenerative lysosomal storage disease, INCL.Maria B. BaghShiyong PengGoutam ChandraZhongjian ZhangSatya P. SinghNagarajan PattabiramanAiyi LiuAnil B. MukherjeeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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Science Q Maria B. Bagh Shiyong Peng Goutam Chandra Zhongjian Zhang Satya P. Singh Nagarajan Pattabiraman Aiyi Liu Anil B. Mukherjee Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model |
description |
Lysosomal acidification defects have been implicated in various neurodegenerative disorders. Baghet al. show that the V0a1 subunit of v-ATPase requires palmitoylation for correct sorting and trafficking to the lysosome membrane, and that such a process is impaired in a mouse model of a devastating neurodegenerative lysosomal storage disease, INCL. |
format |
article |
author |
Maria B. Bagh Shiyong Peng Goutam Chandra Zhongjian Zhang Satya P. Singh Nagarajan Pattabiraman Aiyi Liu Anil B. Mukherjee |
author_facet |
Maria B. Bagh Shiyong Peng Goutam Chandra Zhongjian Zhang Satya P. Singh Nagarajan Pattabiraman Aiyi Liu Anil B. Mukherjee |
author_sort |
Maria B. Bagh |
title |
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model |
title_short |
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model |
title_full |
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model |
title_fullStr |
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model |
title_full_unstemmed |
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model |
title_sort |
misrouting of v-atpase subunit v0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/728ace11a95a4edda7a3da8550cb2ff6 |
work_keys_str_mv |
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1718390244260184064 |