Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

Monoclonal antibodies to prevent respiratory syncytial virus (RSV) disease are under development, but the molecular requirements for cross-subtype neutralization are unclear. Here, the authors show that residue 201 in RSV fusion protein determines subtype specific neutralization for the clinically-r...

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Autores principales:	Daiyin Tian, Michael B. Battles, Syed M. Moin, Man Chen, Kayvon Modjarrad, Azad Kumar, Masaru Kanekiyo, Kevin W. Graepel, Noor M. Taher, Anne L. Hotard, Martin L. Moore, Min Zhao, Zi-Zheng Zheng, Ning-Shao Xia, Jason S. McLellan, Barney S. Graham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72a5be0f154c45639beb660fdd77aff7
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spelling	oai:doaj.org-article:72a5be0f154c45639beb660fdd77aff72021-12-02T14:41:11ZStructural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein10.1038/s41467-017-01858-w2041-1723https://doaj.org/article/72a5be0f154c45639beb660fdd77aff72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01858-whttps://doaj.org/toc/2041-1723Monoclonal antibodies to prevent respiratory syncytial virus (RSV) disease are under development, but the molecular requirements for cross-subtype neutralization are unclear. Here, the authors show that residue 201 in RSV fusion protein determines subtype specific neutralization for the clinically-relevant monoclonal antibody, 5C4.Daiyin TianMichael B. BattlesSyed M. MoinMan ChenKayvon ModjarradAzad KumarMasaru KanekiyoKevin W. GraepelNoor M. TaherAnne L. HotardMartin L. MooreMin ZhaoZi-Zheng ZhengNing-Shao XiaJason S. McLellanBarney S. GrahamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daiyin Tian Michael B. Battles Syed M. Moin Man Chen Kayvon Modjarrad Azad Kumar Masaru Kanekiyo Kevin W. Graepel Noor M. Taher Anne L. Hotard Martin L. Moore Min Zhao Zi-Zheng Zheng Ning-Shao Xia Jason S. McLellan Barney S. Graham Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
description	Monoclonal antibodies to prevent respiratory syncytial virus (RSV) disease are under development, but the molecular requirements for cross-subtype neutralization are unclear. Here, the authors show that residue 201 in RSV fusion protein determines subtype specific neutralization for the clinically-relevant monoclonal antibody, 5C4.
format	article
author	Daiyin Tian Michael B. Battles Syed M. Moin Man Chen Kayvon Modjarrad Azad Kumar Masaru Kanekiyo Kevin W. Graepel Noor M. Taher Anne L. Hotard Martin L. Moore Min Zhao Zi-Zheng Zheng Ning-Shao Xia Jason S. McLellan Barney S. Graham
author_facet	Daiyin Tian Michael B. Battles Syed M. Moin Man Chen Kayvon Modjarrad Azad Kumar Masaru Kanekiyo Kevin W. Graepel Noor M. Taher Anne L. Hotard Martin L. Moore Min Zhao Zi-Zheng Zheng Ning-Shao Xia Jason S. McLellan Barney S. Graham
author_sort	Daiyin Tian
title	Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
title_short	Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
title_full	Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
title_fullStr	Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
title_full_unstemmed	Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
title_sort	structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/72a5be0f154c45639beb660fdd77aff7
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Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

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