An evaluation of approaches for rare variant association analyses of binary traits in related samples

Abstract Recognizing that family data provide unique advantage of identifying rare risk variants in genetic association studies, many cohorts with related samples have gone through whole genome sequencing in large initiatives such as the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. Ana...

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Autores principales: Ming-Huei Chen, Achilleas Pitsillides, Qiong Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/72b245b1894a491e9d3931f638fb49ac
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