Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice

Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice

Summary: miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of miR-216a in mice leads to a reduction in islet size,...

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Auteurs principaux: Suheda Erener, Cara E. Ellis, Adam Ramzy, Maria M. Glavas, Shannon O’Dwyer, Sandra Pereira, Tom Wang, Janice Pang, Jennifer E. Bruin, Michael J. Riedel, Robert K. Baker, Travis D. Webber, Marina Lesina, Matthias Blüher, Hana Algül, Janel L. Kopp, Stephan Herzig, Timothy J. Kieffer
Format: article
Langue:EN
Publié: Elsevier 2021
Sujets:
miR-216a
β-cell mass
diabetes
pancreatic cancer
PDAC
biomarker
Medicine (General)
R5-920
Accès en ligne:https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f
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https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f

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