Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice

Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice

Summary: miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of miR-216a in mice leads to a reduction in islet size,...

Full description

Saved in:
Bibliographic Details
Main Authors: Suheda Erener, Cara E. Ellis, Adam Ramzy, Maria M. Glavas, Shannon O’Dwyer, Sandra Pereira, Tom Wang, Janice Pang, Jennifer E. Bruin, Michael J. Riedel, Robert K. Baker, Travis D. Webber, Marina Lesina, Matthias Blüher, Hana Algül, Janel L. Kopp, Stephan Herzig, Timothy J. Kieffer
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
miR-216a
β-cell mass
diabetes
pancreatic cancer
PDAC
biomarker
Medicine (General)
R5-920
Online Access:https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f

Similar Items