Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity

Mutations inCHCHD10 have been recently associated with frontotemporal dementia and amyotrophic lateral sclerosis. Here the authors study the functions of endogenous CHCHD10 in Caenorhabditis elegans, primary neurons, and mouse, and show that it normally protects mitochondria and synaptic integrity,...

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Autores principales: Jung-A. A. Woo, Tian Liu, Courtney Trotter, Cenxiao C. Fang, Emillio De Narvaez, Patrick LePochat, Drew Maslar, Anusha Bukhari, Xingyu Zhao, Andrew Deonarine, Sandy D. Westerheide, David E. Kang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/72d4780e4d0e4475960c6ed150a0885d
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https://doaj.org/article/72d4780e4d0e4475960c6ed150a0885d

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