Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity

Mutations inCHCHD10 have been recently associated with frontotemporal dementia and amyotrophic lateral sclerosis. Here the authors study the functions of endogenous CHCHD10 in Caenorhabditis elegans, primary neurons, and mouse, and show that it normally protects mitochondria and synaptic integrity,...

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Autores principales:	Jung-A. A. Woo, Tian Liu, Courtney Trotter, Cenxiao C. Fang, Emillio De Narvaez, Patrick LePochat, Drew Maslar, Anusha Bukhari, Xingyu Zhao, Andrew Deonarine, Sandy D. Westerheide, David E. Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72d4780e4d0e4475960c6ed150a0885d
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spelling	oai:doaj.org-article:72d4780e4d0e4475960c6ed150a0885d2021-12-02T14:42:26ZLoss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity10.1038/ncomms155582041-1723https://doaj.org/article/72d4780e4d0e4475960c6ed150a0885d2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15558https://doaj.org/toc/2041-1723Mutations inCHCHD10 have been recently associated with frontotemporal dementia and amyotrophic lateral sclerosis. Here the authors study the functions of endogenous CHCHD10 in Caenorhabditis elegans, primary neurons, and mouse, and show that it normally protects mitochondria and synaptic integrity, and retains TDP-43 in the nucleus.Jung-A. A. WooTian LiuCourtney TrotterCenxiao C. FangEmillio De NarvaezPatrick LePochatDrew MaslarAnusha BukhariXingyu ZhaoAndrew DeonarineSandy D. WesterheideDavid E. KangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-A. A. Woo Tian Liu Courtney Trotter Cenxiao C. Fang Emillio De Narvaez Patrick LePochat Drew Maslar Anusha Bukhari Xingyu Zhao Andrew Deonarine Sandy D. Westerheide David E. Kang Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
description	Mutations inCHCHD10 have been recently associated with frontotemporal dementia and amyotrophic lateral sclerosis. Here the authors study the functions of endogenous CHCHD10 in Caenorhabditis elegans, primary neurons, and mouse, and show that it normally protects mitochondria and synaptic integrity, and retains TDP-43 in the nucleus.
format	article
author	Jung-A. A. Woo Tian Liu Courtney Trotter Cenxiao C. Fang Emillio De Narvaez Patrick LePochat Drew Maslar Anusha Bukhari Xingyu Zhao Andrew Deonarine Sandy D. Westerheide David E. Kang
author_facet	Jung-A. A. Woo Tian Liu Courtney Trotter Cenxiao C. Fang Emillio De Narvaez Patrick LePochat Drew Maslar Anusha Bukhari Xingyu Zhao Andrew Deonarine Sandy D. Westerheide David E. Kang
author_sort	Jung-A. A. Woo
title	Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
title_short	Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
title_full	Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
title_fullStr	Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
title_full_unstemmed	Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
title_sort	loss of function chchd10 mutations in cytoplasmic tdp-43 accumulation and synaptic integrity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/72d4780e4d0e4475960c6ed150a0885d
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Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity

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