The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.

In mammals, the circadian rhythm central generator consists of interactions among clock genes, including Per1/2/3, Cry1/2, Bmal1, and Clock. Circadian rhythm disruption may lead to increased risk of cancer in humans, and deregulation of clock genes has been implicated in many types of cancers. Among...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takashi Okabe, Megumi Kumagai, Yoshihiro Nakajima, Suguru Shirotake, Kiichiro Kodaira, Masafumi Oyama, Munehisa Ueno, Masaaki Ikeda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72d8721dc05a44ef8bbd201ada9b2035
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:72d8721dc05a44ef8bbd201ada9b2035
record_format	dspace
spelling	oai:doaj.org-article:72d8721dc05a44ef8bbd201ada9b20352021-11-25T05:55:41ZThe impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.1932-620310.1371/journal.pone.0109693https://doaj.org/article/72d8721dc05a44ef8bbd201ada9b20352014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109693https://doaj.org/toc/1932-6203In mammals, the circadian rhythm central generator consists of interactions among clock genes, including Per1/2/3, Cry1/2, Bmal1, and Clock. Circadian rhythm disruption may lead to increased risk of cancer in humans, and deregulation of clock genes has been implicated in many types of cancers. Among these genes, Per2 is reported to have tumor suppressor properties, but little is known about the correlation between Per2 and HIF, which is the main target of renal cell carcinoma (RCC) therapy. In this study, the rhythmic expression of the Per2 gene was not detectable in renal cancer cell lines, with the exception of Caki-2 cells. In Caki-2 cells, HIF1α increased the amplitude of Per2 oscillation by directly binding to the HIF-binding site located on the Per2 promoter. These results indicate that HIF1α may enhance the amplitude of the Per2 circadian rhythm.Takashi OkabeMegumi KumagaiYoshihiro NakajimaSuguru ShirotakeKiichiro KodairaMasafumi OyamaMunehisa UenoMasaaki IkedaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109693 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Okabe Megumi Kumagai Yoshihiro Nakajima Suguru Shirotake Kiichiro Kodaira Masafumi Oyama Munehisa Ueno Masaaki Ikeda The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.
description	In mammals, the circadian rhythm central generator consists of interactions among clock genes, including Per1/2/3, Cry1/2, Bmal1, and Clock. Circadian rhythm disruption may lead to increased risk of cancer in humans, and deregulation of clock genes has been implicated in many types of cancers. Among these genes, Per2 is reported to have tumor suppressor properties, but little is known about the correlation between Per2 and HIF, which is the main target of renal cell carcinoma (RCC) therapy. In this study, the rhythmic expression of the Per2 gene was not detectable in renal cancer cell lines, with the exception of Caki-2 cells. In Caki-2 cells, HIF1α increased the amplitude of Per2 oscillation by directly binding to the HIF-binding site located on the Per2 promoter. These results indicate that HIF1α may enhance the amplitude of the Per2 circadian rhythm.
format	article
author	Takashi Okabe Megumi Kumagai Yoshihiro Nakajima Suguru Shirotake Kiichiro Kodaira Masafumi Oyama Munehisa Ueno Masaaki Ikeda
author_facet	Takashi Okabe Megumi Kumagai Yoshihiro Nakajima Suguru Shirotake Kiichiro Kodaira Masafumi Oyama Munehisa Ueno Masaaki Ikeda
author_sort	Takashi Okabe
title	The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.
title_short	The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.
title_full	The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.
title_fullStr	The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.
title_full_unstemmed	The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.
title_sort	impact of hif1α on the per2 circadian rhythm in renal cancer cell lines.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/72d8721dc05a44ef8bbd201ada9b2035
work_keys_str_mv	AT takashiokabe theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT megumikumagai theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT yoshihironakajima theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT sugurushirotake theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT kiichirokodaira theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT masafumioyama theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT munehisaueno theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT masaakiikeda theimpactofhif1aontheper2circadianrhythminrenalcancercelllines AT takashiokabe impactofhif1aontheper2circadianrhythminrenalcancercelllines AT megumikumagai impactofhif1aontheper2circadianrhythminrenalcancercelllines AT yoshihironakajima impactofhif1aontheper2circadianrhythminrenalcancercelllines AT sugurushirotake impactofhif1aontheper2circadianrhythminrenalcancercelllines AT kiichirokodaira impactofhif1aontheper2circadianrhythminrenalcancercelllines AT masafumioyama impactofhif1aontheper2circadianrhythminrenalcancercelllines AT munehisaueno impactofhif1aontheper2circadianrhythminrenalcancercelllines AT masaakiikeda impactofhif1aontheper2circadianrhythminrenalcancercelllines
_version_	1718414347398545408

The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.

Ejemplares similares