Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis
Dysregulation of synovial fibroblasts is thought to be an important step in the pathogenesis of rheumatoid arthritis. Here the authors implicate α2-6 sialylation in this process by studying the glycome of these cells in patients and in a mouse model of inflammatory joint disease.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/72dfa842353344fcbc847fcee0909af2 |
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oai:doaj.org-article:72dfa842353344fcbc847fcee0909af22021-12-02T18:28:38ZLoss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis10.1038/s41467-021-22365-z2041-1723https://doaj.org/article/72dfa842353344fcbc847fcee0909af22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22365-zhttps://doaj.org/toc/2041-1723Dysregulation of synovial fibroblasts is thought to be an important step in the pathogenesis of rheumatoid arthritis. Here the authors implicate α2-6 sialylation in this process by studying the glycome of these cells in patients and in a mouse model of inflammatory joint disease.Yilin WangAneesah KhanAristotelis AntonopoulosLaura BouchéChristopher D. BuckleyAndrew FilerKarim RazaKun-Ping LiBarbara TolussoElisa GremeseMariola Kurowska-StolarskaStefano AliverniniAnne DellStuart M. HaslamMiguel A. PinedaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yilin Wang Aneesah Khan Aristotelis Antonopoulos Laura Bouché Christopher D. Buckley Andrew Filer Karim Raza Kun-Ping Li Barbara Tolusso Elisa Gremese Mariola Kurowska-Stolarska Stefano Alivernini Anne Dell Stuart M. Haslam Miguel A. Pineda Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis |
| description |
Dysregulation of synovial fibroblasts is thought to be an important step in the pathogenesis of rheumatoid arthritis. Here the authors implicate α2-6 sialylation in this process by studying the glycome of these cells in patients and in a mouse model of inflammatory joint disease. |
| format |
article |
| author |
Yilin Wang Aneesah Khan Aristotelis Antonopoulos Laura Bouché Christopher D. Buckley Andrew Filer Karim Raza Kun-Ping Li Barbara Tolusso Elisa Gremese Mariola Kurowska-Stolarska Stefano Alivernini Anne Dell Stuart M. Haslam Miguel A. Pineda |
| author_facet |
Yilin Wang Aneesah Khan Aristotelis Antonopoulos Laura Bouché Christopher D. Buckley Andrew Filer Karim Raza Kun-Ping Li Barbara Tolusso Elisa Gremese Mariola Kurowska-Stolarska Stefano Alivernini Anne Dell Stuart M. Haslam Miguel A. Pineda |
| author_sort |
Yilin Wang |
| title |
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis |
| title_short |
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis |
| title_full |
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis |
| title_fullStr |
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis |
| title_full_unstemmed |
Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis |
| title_sort |
loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/72dfa842353344fcbc847fcee0909af2 |
| work_keys_str_mv |
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