C-edge loops of arrestin function as a membrane anchor

The activity of G-protein-coupled receptors is regulated by their interaction with arrestins. Here the authors show that loops located on C-edge of arrestin-1 serve as a membrane anchor during the multi-step binding process that leads to a stable receptor–arrestin complex.

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Autores principales:	Ciara C M. Lally, Brian Bauer, Jana Selent, Martha E Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72e83b7d836d45689db64162e5a82405
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spelling	oai:doaj.org-article:72e83b7d836d45689db64162e5a824052021-12-02T17:06:06ZC-edge loops of arrestin function as a membrane anchor10.1038/ncomms142582041-1723https://doaj.org/article/72e83b7d836d45689db64162e5a824052017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14258https://doaj.org/toc/2041-1723The activity of G-protein-coupled receptors is regulated by their interaction with arrestins. Here the authors show that loops located on C-edge of arrestin-1 serve as a membrane anchor during the multi-step binding process that leads to a stable receptor–arrestin complex.Ciara C M. LallyBrian BauerJana SelentMartha E SommerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ciara C M. Lally Brian Bauer Jana Selent Martha E Sommer C-edge loops of arrestin function as a membrane anchor
description	The activity of G-protein-coupled receptors is regulated by their interaction with arrestins. Here the authors show that loops located on C-edge of arrestin-1 serve as a membrane anchor during the multi-step binding process that leads to a stable receptor–arrestin complex.
format	article
author	Ciara C M. Lally Brian Bauer Jana Selent Martha E Sommer
author_facet	Ciara C M. Lally Brian Bauer Jana Selent Martha E Sommer
author_sort	Ciara C M. Lally
title	C-edge loops of arrestin function as a membrane anchor
title_short	C-edge loops of arrestin function as a membrane anchor
title_full	C-edge loops of arrestin function as a membrane anchor
title_fullStr	C-edge loops of arrestin function as a membrane anchor
title_full_unstemmed	C-edge loops of arrestin function as a membrane anchor
title_sort	c-edge loops of arrestin function as a membrane anchor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/72e83b7d836d45689db64162e5a82405
work_keys_str_mv	AT ciaracmlally cedgeloopsofarrestinfunctionasamembraneanchor AT brianbauer cedgeloopsofarrestinfunctionasamembraneanchor AT janaselent cedgeloopsofarrestinfunctionasamembraneanchor AT marthaesommer cedgeloopsofarrestinfunctionasamembraneanchor
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C-edge loops of arrestin function as a membrane anchor

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