Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy

Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy

Programmed cell death-1 (PD-1) blockade has a profound effect on the ability of the immune system to eliminate tumors, but many questions remain about the cell types involved and the underlying mechanisms of immune activation. To shed some light on this, the cellular and molecular events following i...

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Main Authors: Sukanya Raghavan, Nataliya Tovbis-Shifrin, Christina Kochel, Anandi Sawant, Marielle Mello, Manjiri Sathe, Wendy Blumenschein, Eric S. Muise, Alissa Chackerian, Elaine M. Pinheiro, Thomas W. Rosahl, Hervé Luche, Rene de Waal Malefyt
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
conditional KO mice
IFN gamma
PD-1
mass cytometry (CyTOF)
tumor immunity and immunotherapy
CD8 T cell
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/72fd7ab5d05749e780b38e08a7d4a277
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https://doaj.org/article/72fd7ab5d05749e780b38e08a7d4a277

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