Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

ABSTRACT The global spread of antibiotic resistance among Enterobacteriaceae is largely due to multidrug resistance plasmids that can transfer between different bacterial strains and species. Horizontal gene transfer of resistance plasmids can complicate hospital outbreaks and cause problems in epid...

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Main Authors: Santosh K. Bikkarolla, Viveka Nordberg, Fredrika Rajer, Vilhelm Müller, Muhammad Humaun Kabir, Sriram KK, Albertas Dvirnas, Tobias Ambjörnsson, Christian G. Giske, Lars Navér, Linus Sandegren, Fredrik Westerlund
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
CRISPR/Cas9
optical DNA mapping
antibiotic resistance
intensive care unit
plasmids
Microbiology
QR1-502
Online Access:https://doaj.org/article/730b4c91ff0a497f8391279efab4bee3
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https://doaj.org/article/730b4c91ff0a497f8391279efab4bee3

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