Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
The VASH2/SVBP heterodimer catalyzes the detyrosination of the α-tubulin C-terminus. Here the authors provide insights into the tubulin detyrosination mechanism by determining the crystal structures of VASH2/SVBP and VASH2/SVBP in complex with a tubulin tail peptide.
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Nature Portfolio
2019
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oai:doaj.org-article:73149a2dc2634b788e4b85463c6af74a2021-12-02T16:50:58ZStructural basis of tubulin detyrosination by VASH2/SVBP heterodimer10.1038/s41467-019-11277-82041-1723https://doaj.org/article/73149a2dc2634b788e4b85463c6af74a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11277-8https://doaj.org/toc/2041-1723The VASH2/SVBP heterodimer catalyzes the detyrosination of the α-tubulin C-terminus. Here the authors provide insights into the tubulin detyrosination mechanism by determining the crystal structures of VASH2/SVBP and VASH2/SVBP in complex with a tubulin tail peptide.Chen ZhouLing YanWen-hui ZhangZhu LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019) |
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Science Q Chen Zhou Ling Yan Wen-hui Zhang Zhu Liu Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer |
description |
The VASH2/SVBP heterodimer catalyzes the detyrosination of the α-tubulin C-terminus. Here the authors provide insights into the tubulin detyrosination mechanism by determining the crystal structures of VASH2/SVBP and VASH2/SVBP in complex with a tubulin tail peptide. |
format |
article |
author |
Chen Zhou Ling Yan Wen-hui Zhang Zhu Liu |
author_facet |
Chen Zhou Ling Yan Wen-hui Zhang Zhu Liu |
author_sort |
Chen Zhou |
title |
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer |
title_short |
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer |
title_full |
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer |
title_fullStr |
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer |
title_full_unstemmed |
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer |
title_sort |
structural basis of tubulin detyrosination by vash2/svbp heterodimer |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/73149a2dc2634b788e4b85463c6af74a |
work_keys_str_mv |
AT chenzhou structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer AT lingyan structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer AT wenhuizhang structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer AT zhuliu structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer |
_version_ |
1718382984381333504 |