Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer

The VASH2/SVBP heterodimer catalyzes the detyrosination of the α-tubulin C-terminus. Here the authors provide insights into the tubulin detyrosination mechanism by determining the crystal structures of VASH2/SVBP and VASH2/SVBP in complex with a tubulin tail peptide.

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Autores principales: Chen Zhou, Ling Yan, Wen-hui Zhang, Zhu Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/73149a2dc2634b788e4b85463c6af74a
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spelling oai:doaj.org-article:73149a2dc2634b788e4b85463c6af74a2021-12-02T16:50:58ZStructural basis of tubulin detyrosination by VASH2/SVBP heterodimer10.1038/s41467-019-11277-82041-1723https://doaj.org/article/73149a2dc2634b788e4b85463c6af74a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11277-8https://doaj.org/toc/2041-1723The VASH2/SVBP heterodimer catalyzes the detyrosination of the α-tubulin C-terminus. Here the authors provide insights into the tubulin detyrosination mechanism by determining the crystal structures of VASH2/SVBP and VASH2/SVBP in complex with a tubulin tail peptide.Chen ZhouLing YanWen-hui ZhangZhu LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chen Zhou
Ling Yan
Wen-hui Zhang
Zhu Liu
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
description The VASH2/SVBP heterodimer catalyzes the detyrosination of the α-tubulin C-terminus. Here the authors provide insights into the tubulin detyrosination mechanism by determining the crystal structures of VASH2/SVBP and VASH2/SVBP in complex with a tubulin tail peptide.
format article
author Chen Zhou
Ling Yan
Wen-hui Zhang
Zhu Liu
author_facet Chen Zhou
Ling Yan
Wen-hui Zhang
Zhu Liu
author_sort Chen Zhou
title Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
title_short Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
title_full Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
title_fullStr Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
title_full_unstemmed Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
title_sort structural basis of tubulin detyrosination by vash2/svbp heterodimer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/73149a2dc2634b788e4b85463c6af74a
work_keys_str_mv AT chenzhou structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer
AT lingyan structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer
AT wenhuizhang structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer
AT zhuliu structuralbasisoftubulindetyrosinationbyvash2svbpheterodimer
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