High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients

In vitro chemotactic assays are often 2D, low-throughput and lack fine gradient control. Here the authors present a hydrogel-based microfluidic platform for high-throughput 3D chemotactic assays, and use it to study neuronal sensitivity to guidance molecule gradient steepness.

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Autores principales: Zhen Xu, Peilin Fang, Bingzhe Xu, Yufeng Lu, Jinghui Xiong, Feng Gao, Xin Wang, Jun Fan, Peng Shi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7319b5646b654ef192654ef80c5613a9
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