FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals.

FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals.

We propose a novel multifactor dimensionality reduction method for epistasis detection in small or extended pedigrees, FAM-MDR. It combines features of the Genome-wide Rapid Association using Mixed Model And Regression approach (GRAMMAR) with Model-Based MDR (MB-MDR). We focus on continuous traits,...

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Autores principales: Tom Cattaert, Víctor Urrea, Adam C Naj, Lizzy De Lobel, Vanessa De Wit, Mao Fu, Jestinah M Mahachie John, Haiqing Shen, M Luz Calle, Marylyn D Ritchie, Todd L Edwards, Kristel Van Steen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/73364a32f96349eebd6e6cf8ab957a95
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https://doaj.org/article/73364a32f96349eebd6e6cf8ab957a95

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