Transforming early pharmaceutical assessment of genotoxicity: applying statistical learning to a high throughput, multi end point in vitro micronucleus assay

Abstract To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers assoc...

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Autores principales: Amy Wilson, Piotr Grabowski, Joanne Elloway, Stephanie Ling, Jonathan Stott, Ann Doherty
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/734ce7250fa54c68a6acc32cb4966de1
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