Transforming early pharmaceutical assessment of genotoxicity: applying statistical learning to a high throughput, multi end point in vitro micronucleus assay
Abstract To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers assoc...
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Autores principales: | Amy Wilson, Piotr Grabowski, Joanne Elloway, Stephanie Ling, Jonathan Stott, Ann Doherty |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/734ce7250fa54c68a6acc32cb4966de1 |
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