Targeted Quantification of Carbon Metabolites Identifies Metabolic Progression Markers and an Undiagnosed Case of SDH-Deficient Clear Cell Renal Cell Carcinoma in a German Cohort

Targeted Quantification of Carbon Metabolites Identifies Metabolic Progression Markers and an Undiagnosed Case of SDH-Deficient Clear Cell Renal Cell Carcinoma in a German Cohort

Renal cell carcinoma (RCC) is among the 10 most common cancer entities and can be categorised into distinct subtypes by differential expression of Krebs cycle genes. We investigated the predictive value of several targeted metabolites with regards to tumour stages and patient survival in an unselect...

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Autores principales: Doreen William, Kati Erdmann, Jonas Ottemöller, Anastasios Mangelis, Catleen Conrad, Mirko Peitzsch, Evelin Schröck, Graeme Eisenhofer, Aristeidis Zacharis, Susanne Füssel, Daniela Aust, Barbara Klink, Susan Richter
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
Krebs cycle
metabolic profiling
renal cell carcinoma
subtypes
survival analysis
succinate dehydrogenase mutations
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/737c8718eab247f0abc5488e82bb525a
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https://doaj.org/article/737c8718eab247f0abc5488e82bb525a

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