Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.

Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.

The purpose of our study was to understand if Toll-like receptor 9 (TLR9) activation could contribute to the control of inflammation in Sjogren's syndrome. To this end, we manipulated TLR9 signaling in non-obese diabetic (NOD) and TLR9(-/-) mice using agonistic CpG oligonucleotide aptamers, TLR...

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Bibliographic Details
Main Authors: Adi Gilboa-Geffen, Yochai Wolf, Geula Hanin, Naomi Melamed-Book, Marjorie Pick, Estelle R Bennett, David S Greenberg, Susan Lester, Maureen Rischmueller, Hermona Soreq
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/738cb2a18b1149fca36a75e04b8ee92c
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https://doaj.org/article/738cb2a18b1149fca36a75e04b8ee92c

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