Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study

Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study

Summary: Background: Emergency admissions for infection often lack initial diagnostic certainty. COVID-19 has highlighted a need for novel diagnostic approaches to indicate likelihood of viral infection in a pandemic setting. We aimed to derive and validate a blood transcriptional signature to dete...

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Main Authors: Ho Kwong Li, MRCP, Myrsini Kaforou, PhD, Jesus Rodriguez-Manzano, PhD, Samuel Channon-Wells, MMath, Ahmad Moniri, MEng, Dominic Habgood-Coote, MSc, Rishi K Gupta, MRCP, Ewurabena A Mills, BSc, Dominique Arancon, BSN, Jessica Lin, MRes, Yueh-Ho Chiu, PhD, Ivana Pennisi, MSc, Luca Miglietta, MSc, Ravi Mehta, MRCP, Nelofar Obaray, PhD, Jethro A Herberg, PhD, Victoria J Wright, PhD, Pantelis Georgiou, PhD, Laura J Shallcross, PhD, Alexander J Mentzer, DPhil, Michael Levin, ProfPhD, Graham S Cooke, ProfDPhil, Mahdad Noursadeghi, ProfPhD, Shiranee Sriskandan, ProfPhD
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Medicine (General)
R5-920
Microbiology
QR1-502
Online Access:https://doaj.org/article/73aa9043bc534c35a99d2626cfacd305
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https://doaj.org/article/73aa9043bc534c35a99d2626cfacd305

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