Structural basis of seamless excision and specific targeting by piggyBac transposase

PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transpos...

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Auteurs principaux: Qiujia Chen, Wentian Luo, Ruth Ann Veach, Alison B. Hickman, Matthew H. Wilson, Fred Dyda
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/73fcb349e4bd4561984b0e66066d5196
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