Structural basis of seamless excision and specific targeting by piggyBac transposase

PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transpos...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Qiujia Chen, Wentian Luo, Ruth Ann Veach, Alison B. Hickman, Matthew H. Wilson, Fred Dyda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/73fcb349e4bd4561984b0e66066d5196
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transposition reaction proceeds.