Structural basis of seamless excision and specific targeting by piggyBac transposase

PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transpos...

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Autores principales:	Qiujia Chen, Wentian Luo, Ruth Ann Veach, Alison B. Hickman, Matthew H. Wilson, Fred Dyda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73fcb349e4bd4561984b0e66066d5196
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spelling	oai:doaj.org-article:73fcb349e4bd4561984b0e66066d51962021-12-02T15:23:19ZStructural basis of seamless excision and specific targeting by piggyBac transposase10.1038/s41467-020-17128-12041-1723https://doaj.org/article/73fcb349e4bd4561984b0e66066d51962020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17128-1https://doaj.org/toc/2041-1723PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transposition reaction proceeds.Qiujia ChenWentian LuoRuth Ann VeachAlison B. HickmanMatthew H. WilsonFred DydaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiujia Chen Wentian Luo Ruth Ann Veach Alison B. Hickman Matthew H. Wilson Fred Dyda Structural basis of seamless excision and specific targeting by piggyBac transposase
description	PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transposition reaction proceeds.
format	article
author	Qiujia Chen Wentian Luo Ruth Ann Veach Alison B. Hickman Matthew H. Wilson Fred Dyda
author_facet	Qiujia Chen Wentian Luo Ruth Ann Veach Alison B. Hickman Matthew H. Wilson Fred Dyda
author_sort	Qiujia Chen
title	Structural basis of seamless excision and specific targeting by piggyBac transposase
title_short	Structural basis of seamless excision and specific targeting by piggyBac transposase
title_full	Structural basis of seamless excision and specific targeting by piggyBac transposase
title_fullStr	Structural basis of seamless excision and specific targeting by piggyBac transposase
title_full_unstemmed	Structural basis of seamless excision and specific targeting by piggyBac transposase
title_sort	structural basis of seamless excision and specific targeting by piggybac transposase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/73fcb349e4bd4561984b0e66066d5196
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Structural basis of seamless excision and specific targeting by piggyBac transposase

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