Glutaredoxin catalysis requires two distinct glutathione interaction sites

Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.

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Autores principales: Patricia Begas, Linda Liedgens, Anna Moseler, Andreas J. Meyer, Marcel Deponte
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/740639bdf8af4d88af583ed4dd6926cd
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