Glutaredoxin catalysis requires two distinct glutathione interaction sites

Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.

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Detalles Bibliográficos
Autores principales:	Patricia Begas, Linda Liedgens, Anna Moseler, Andreas J. Meyer, Marcel Deponte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/740639bdf8af4d88af583ed4dd6926cd
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spelling	oai:doaj.org-article:740639bdf8af4d88af583ed4dd6926cd2021-12-02T17:06:26ZGlutaredoxin catalysis requires two distinct glutathione interaction sites10.1038/ncomms148352041-1723https://doaj.org/article/740639bdf8af4d88af583ed4dd6926cd2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14835https://doaj.org/toc/2041-1723Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.Patricia BegasLinda LiedgensAnna MoselerAndreas J. MeyerMarcel DeponteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia Begas Linda Liedgens Anna Moseler Andreas J. Meyer Marcel Deponte Glutaredoxin catalysis requires two distinct glutathione interaction sites
description	Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating glutathione as a reducing agent.
format	article
author	Patricia Begas Linda Liedgens Anna Moseler Andreas J. Meyer Marcel Deponte
author_facet	Patricia Begas Linda Liedgens Anna Moseler Andreas J. Meyer Marcel Deponte
author_sort	Patricia Begas
title	Glutaredoxin catalysis requires two distinct glutathione interaction sites
title_short	Glutaredoxin catalysis requires two distinct glutathione interaction sites
title_full	Glutaredoxin catalysis requires two distinct glutathione interaction sites
title_fullStr	Glutaredoxin catalysis requires two distinct glutathione interaction sites
title_full_unstemmed	Glutaredoxin catalysis requires two distinct glutathione interaction sites
title_sort	glutaredoxin catalysis requires two distinct glutathione interaction sites
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/740639bdf8af4d88af583ed4dd6926cd
work_keys_str_mv	AT patriciabegas glutaredoxincatalysisrequirestwodistinctglutathioneinteractionsites AT lindaliedgens glutaredoxincatalysisrequirestwodistinctglutathioneinteractionsites AT annamoseler glutaredoxincatalysisrequirestwodistinctglutathioneinteractionsites AT andreasjmeyer glutaredoxincatalysisrequirestwodistinctglutathioneinteractionsites AT marceldeponte glutaredoxincatalysisrequirestwodistinctglutathioneinteractionsites
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Glutaredoxin catalysis requires two distinct glutathione interaction sites

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