Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair

In Escherichia coli, the UvrAB damage sensor recognizes helix-distorting lesions by itself or via Mfd bound to stalled RNA polymerase. Here authors use single-molecule fluorescence imaging to quantify the kinetic signatures of interactions of UvrA with Mfd and UvrB in live cells.

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Autores principales:	Harshad Ghodke, Han Ngoc Ho, Antoine M. van Oijen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/740952bd81dd4cec999c0b5ba80ed116
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spelling	oai:doaj.org-article:740952bd81dd4cec999c0b5ba80ed1162021-12-02T15:39:10ZSingle-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair10.1038/s41467-020-15179-y2041-1723https://doaj.org/article/740952bd81dd4cec999c0b5ba80ed1162020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15179-yhttps://doaj.org/toc/2041-1723In Escherichia coli, the UvrAB damage sensor recognizes helix-distorting lesions by itself or via Mfd bound to stalled RNA polymerase. Here authors use single-molecule fluorescence imaging to quantify the kinetic signatures of interactions of UvrA with Mfd and UvrB in live cells.Harshad GhodkeHan Ngoc HoAntoine M. van OijenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Harshad Ghodke Han Ngoc Ho Antoine M. van Oijen Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
description	In Escherichia coli, the UvrAB damage sensor recognizes helix-distorting lesions by itself or via Mfd bound to stalled RNA polymerase. Here authors use single-molecule fluorescence imaging to quantify the kinetic signatures of interactions of UvrA with Mfd and UvrB in live cells.
format	article
author	Harshad Ghodke Han Ngoc Ho Antoine M. van Oijen
author_facet	Harshad Ghodke Han Ngoc Ho Antoine M. van Oijen
author_sort	Harshad Ghodke
title	Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
title_short	Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
title_full	Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
title_fullStr	Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
title_full_unstemmed	Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
title_sort	single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/740952bd81dd4cec999c0b5ba80ed116
work_keys_str_mv	AT harshadghodke singlemoleculelivecellimagingvisualizesparallelpathwaysofprokaryoticnucleotideexcisionrepair AT hanngocho singlemoleculelivecellimagingvisualizesparallelpathwaysofprokaryoticnucleotideexcisionrepair AT antoinemvanoijen singlemoleculelivecellimagingvisualizesparallelpathwaysofprokaryoticnucleotideexcisionrepair
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Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair

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