SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo
Abstract Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation. Strikingly, Slc10a4 −/− bone marrow-derived mast cel...
Enregistré dans:
Auteurs principaux: | Hanna Pettersson, Behdad Zarnegar, Annika Westin, Viktor Persson, Christiane Peuckert, Jörgen Jonsson, Jenny Hallgren, Klas Kullander |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/741c7a5b20964df38f985281738b71f6 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation.
par: Agnes E Coutinho, et autres
Publié: (2013) -
IgE by itself affects mature rat mast cell preformed and de novo-synthesized mediator release and amplifies mast cell migratory response.
par: Aleksandra Słodka, et autres
Publié: (2013) -
Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line.
par: Reiji Kojima, et autres
Publié: (2014) -
Calcineurin Aα Contributes to IgE-Dependent Mast-Cell Mediator Secretion in Allergic Inflammation
par: Edwin Leong, et autres
Publié: (2021) -
IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
par: Binh L. Phong, et autres
Publié: (2021)