Gene inversion potentiates bacterial evolvability and virulence

Head-on replication-transcription collisions occur within genes encoded on the lagging DNA strand. Here, the authors show that a large number of originally co-oriented (leading strand) genes have inverted to the head-on orientation, increasing both gene-specific mutation rates, and the overall evolv...

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Auteurs principaux:	Christopher N. Merrikh, Houra Merrikh
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/748c22c4a9c74affa497eacf1ecb4be1
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id	oai:doaj.org-article:748c22c4a9c74affa497eacf1ecb4be1
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spelling	oai:doaj.org-article:748c22c4a9c74affa497eacf1ecb4be12021-12-02T14:41:06ZGene inversion potentiates bacterial evolvability and virulence10.1038/s41467-018-07110-32041-1723https://doaj.org/article/748c22c4a9c74affa497eacf1ecb4be12018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07110-3https://doaj.org/toc/2041-1723Head-on replication-transcription collisions occur within genes encoded on the lagging DNA strand. Here, the authors show that a large number of originally co-oriented (leading strand) genes have inverted to the head-on orientation, increasing both gene-specific mutation rates, and the overall evolvability of several bacterial pathogens.Christopher N. MerrikhHoura MerrikhNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher N. Merrikh Houra Merrikh Gene inversion potentiates bacterial evolvability and virulence
description	Head-on replication-transcription collisions occur within genes encoded on the lagging DNA strand. Here, the authors show that a large number of originally co-oriented (leading strand) genes have inverted to the head-on orientation, increasing both gene-specific mutation rates, and the overall evolvability of several bacterial pathogens.
format	article
author	Christopher N. Merrikh Houra Merrikh
author_facet	Christopher N. Merrikh Houra Merrikh
author_sort	Christopher N. Merrikh
title	Gene inversion potentiates bacterial evolvability and virulence
title_short	Gene inversion potentiates bacterial evolvability and virulence
title_full	Gene inversion potentiates bacterial evolvability and virulence
title_fullStr	Gene inversion potentiates bacterial evolvability and virulence
title_full_unstemmed	Gene inversion potentiates bacterial evolvability and virulence
title_sort	gene inversion potentiates bacterial evolvability and virulence
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/748c22c4a9c74affa497eacf1ecb4be1
work_keys_str_mv	AT christophernmerrikh geneinversionpotentiatesbacterialevolvabilityandvirulence AT houramerrikh geneinversionpotentiatesbacterialevolvabilityandvirulence
_version_	1718389998005256192

Gene inversion potentiates bacterial evolvability and virulence

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