Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopathy and promotes destabilization of the cardiomyoc...

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Autores principales: Tobias G. Schips, Davy Vanhoutte, Alexander Vo, Robert N. Correll, Matthew J. Brody, Hadi Khalil, Jason Karch, Andoria Tjondrokoesoemo, Michelle A. Sargent, Marjorie Maillet, Robert S. Ross, Jeffery D. Molkentin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/74b8489711b44584b0c9cd975dc56e06
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