Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopathy and promotes destabilization of the cardiomyoc...

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Autores principales:	Tobias G. Schips, Davy Vanhoutte, Alexander Vo, Robert N. Correll, Matthew J. Brody, Hadi Khalil, Jason Karch, Andoria Tjondrokoesoemo, Michelle A. Sargent, Marjorie Maillet, Robert S. Ross, Jeffery D. Molkentin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74b8489711b44584b0c9cd975dc56e06
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spelling	oai:doaj.org-article:74b8489711b44584b0c9cd975dc56e062021-12-02T14:38:39ZThrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability10.1038/s41467-018-08026-82041-1723https://doaj.org/article/74b8489711b44584b0c9cd975dc56e062019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08026-8https://doaj.org/toc/2041-1723Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopathy and promotes destabilization of the cardiomyocyte membrane by impairing integrin trafficking to the sarcolemma.Tobias G. SchipsDavy VanhoutteAlexander VoRobert N. CorrellMatthew J. BrodyHadi KhalilJason KarchAndoria TjondrokoesoemoMichelle A. SargentMarjorie MailletRobert S. RossJeffery D. MolkentinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tobias G. Schips Davy Vanhoutte Alexander Vo Robert N. Correll Matthew J. Brody Hadi Khalil Jason Karch Andoria Tjondrokoesoemo Michelle A. Sargent Marjorie Maillet Robert S. Ross Jeffery D. Molkentin Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
description	Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopathy and promotes destabilization of the cardiomyocyte membrane by impairing integrin trafficking to the sarcolemma.
format	article
author	Tobias G. Schips Davy Vanhoutte Alexander Vo Robert N. Correll Matthew J. Brody Hadi Khalil Jason Karch Andoria Tjondrokoesoemo Michelle A. Sargent Marjorie Maillet Robert S. Ross Jeffery D. Molkentin
author_facet	Tobias G. Schips Davy Vanhoutte Alexander Vo Robert N. Correll Matthew J. Brody Hadi Khalil Jason Karch Andoria Tjondrokoesoemo Michelle A. Sargent Marjorie Maillet Robert S. Ross Jeffery D. Molkentin
author_sort	Tobias G. Schips
title	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
title_short	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
title_full	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
title_fullStr	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
title_full_unstemmed	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
title_sort	thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/74b8489711b44584b0c9cd975dc56e06
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Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

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