Bayesian reassessment of the epigenetic architecture of complex traits

Linking epigenetic marks to clinical outcomes promises insight into the underlying processes. Here, the authors introduce a statistical approach to estimate associations between a phenotype and all epigenetic probes jointly, and to estimate the proportion of variation captured by epigenetic effects.

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Detalles Bibliográficos
Autores principales:	Daniel Trejo Banos, Daniel L. McCartney, Marion Patxot, Lucas Anchieri, Thomas Battram, Colette Christiansen, Ricardo Costeira, Rosie M. Walker, Stewart W. Morris, Archie Campbell, Qian Zhang, David J. Porteous, Allan F. McRae, Naomi R. Wray, Peter M. Visscher, Chris S. Haley, Kathryn L. Evans, Ian J. Deary, Andrew M. McIntosh, Gibran Hemani, Jordana T. Bell, Riccardo E. Marioni, Matthew R. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74bbcbe2232d46d983d1a26fad579404
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spelling	oai:doaj.org-article:74bbcbe2232d46d983d1a26fad5794042021-12-02T14:58:24ZBayesian reassessment of the epigenetic architecture of complex traits10.1038/s41467-020-16520-12041-1723https://doaj.org/article/74bbcbe2232d46d983d1a26fad5794042020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16520-1https://doaj.org/toc/2041-1723Linking epigenetic marks to clinical outcomes promises insight into the underlying processes. Here, the authors introduce a statistical approach to estimate associations between a phenotype and all epigenetic probes jointly, and to estimate the proportion of variation captured by epigenetic effects.Daniel Trejo BanosDaniel L. McCartneyMarion PatxotLucas AnchieriThomas BattramColette ChristiansenRicardo CosteiraRosie M. WalkerStewart W. MorrisArchie CampbellQian ZhangDavid J. PorteousAllan F. McRaeNaomi R. WrayPeter M. VisscherChris S. HaleyKathryn L. EvansIan J. DearyAndrew M. McIntoshGibran HemaniJordana T. BellRiccardo E. MarioniMatthew R. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Trejo Banos Daniel L. McCartney Marion Patxot Lucas Anchieri Thomas Battram Colette Christiansen Ricardo Costeira Rosie M. Walker Stewart W. Morris Archie Campbell Qian Zhang David J. Porteous Allan F. McRae Naomi R. Wray Peter M. Visscher Chris S. Haley Kathryn L. Evans Ian J. Deary Andrew M. McIntosh Gibran Hemani Jordana T. Bell Riccardo E. Marioni Matthew R. Robinson Bayesian reassessment of the epigenetic architecture of complex traits
description	Linking epigenetic marks to clinical outcomes promises insight into the underlying processes. Here, the authors introduce a statistical approach to estimate associations between a phenotype and all epigenetic probes jointly, and to estimate the proportion of variation captured by epigenetic effects.
format	article
author	Daniel Trejo Banos Daniel L. McCartney Marion Patxot Lucas Anchieri Thomas Battram Colette Christiansen Ricardo Costeira Rosie M. Walker Stewart W. Morris Archie Campbell Qian Zhang David J. Porteous Allan F. McRae Naomi R. Wray Peter M. Visscher Chris S. Haley Kathryn L. Evans Ian J. Deary Andrew M. McIntosh Gibran Hemani Jordana T. Bell Riccardo E. Marioni Matthew R. Robinson
author_facet	Daniel Trejo Banos Daniel L. McCartney Marion Patxot Lucas Anchieri Thomas Battram Colette Christiansen Ricardo Costeira Rosie M. Walker Stewart W. Morris Archie Campbell Qian Zhang David J. Porteous Allan F. McRae Naomi R. Wray Peter M. Visscher Chris S. Haley Kathryn L. Evans Ian J. Deary Andrew M. McIntosh Gibran Hemani Jordana T. Bell Riccardo E. Marioni Matthew R. Robinson
author_sort	Daniel Trejo Banos
title	Bayesian reassessment of the epigenetic architecture of complex traits
title_short	Bayesian reassessment of the epigenetic architecture of complex traits
title_full	Bayesian reassessment of the epigenetic architecture of complex traits
title_fullStr	Bayesian reassessment of the epigenetic architecture of complex traits
title_full_unstemmed	Bayesian reassessment of the epigenetic architecture of complex traits
title_sort	bayesian reassessment of the epigenetic architecture of complex traits
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/74bbcbe2232d46d983d1a26fad579404
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Bayesian reassessment of the epigenetic architecture of complex traits

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