Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis

Streptovaricin C is an antibiotic containing a methylenedioxy bridge (MDB) moiety essential for its activity. Here, the authors show that a P450 monooxygenase StvP2 catalyses MDB formation, report its crystal structure in complex with the substrate, and elucidate mechanistic details of MDB formation...

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Autores principales:	Guo Sun, Chaoqun Hu, Qing Mei, Minghe Luo, Xu Chen, Zhengyuan Li, Yuanzhen Liu, Zixin Deng, Zhengyu Zhang, Yuhui Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74c1a4c7ed324d9bbb18fb0e408b230a
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spelling	oai:doaj.org-article:74c1a4c7ed324d9bbb18fb0e408b230a2021-12-02T14:55:09ZUncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis10.1038/s41467-020-18336-52041-1723https://doaj.org/article/74c1a4c7ed324d9bbb18fb0e408b230a2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18336-5https://doaj.org/toc/2041-1723Streptovaricin C is an antibiotic containing a methylenedioxy bridge (MDB) moiety essential for its activity. Here, the authors show that a P450 monooxygenase StvP2 catalyses MDB formation, report its crystal structure in complex with the substrate, and elucidate mechanistic details of MDB formation.Guo SunChaoqun HuQing MeiMinghe LuoXu ChenZhengyuan LiYuanzhen LiuZixin DengZhengyu ZhangYuhui SunNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guo Sun Chaoqun Hu Qing Mei Minghe Luo Xu Chen Zhengyuan Li Yuanzhen Liu Zixin Deng Zhengyu Zhang Yuhui Sun Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
description	Streptovaricin C is an antibiotic containing a methylenedioxy bridge (MDB) moiety essential for its activity. Here, the authors show that a P450 monooxygenase StvP2 catalyses MDB formation, report its crystal structure in complex with the substrate, and elucidate mechanistic details of MDB formation.
format	article
author	Guo Sun Chaoqun Hu Qing Mei Minghe Luo Xu Chen Zhengyuan Li Yuanzhen Liu Zixin Deng Zhengyu Zhang Yuhui Sun
author_facet	Guo Sun Chaoqun Hu Qing Mei Minghe Luo Xu Chen Zhengyuan Li Yuanzhen Liu Zixin Deng Zhengyu Zhang Yuhui Sun
author_sort	Guo Sun
title	Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
title_short	Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
title_full	Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
title_fullStr	Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
title_full_unstemmed	Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
title_sort	uncovering the cytochrome p450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/74c1a4c7ed324d9bbb18fb0e408b230a
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Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis

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