The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells

Epigenetic regulation is critical for the maintenance of germ cell identity. Here the authors show that H3K9me3-mediated gene silencing is critical for repression of testis-specific transcription in Drosophila female germ cells, indicating H3K9me3 maintains female germ cell sexual identity.

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Autores principales:	Anne E. Smolko, Laura Shapiro-Kulnane, Helen K. Salz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74ebcd160d7e4074aa11e9e361e200e3
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spelling	oai:doaj.org-article:74ebcd160d7e4074aa11e9e361e200e32021-12-02T16:49:55ZThe H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells10.1038/s41467-018-06697-x2041-1723https://doaj.org/article/74ebcd160d7e4074aa11e9e361e200e32018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06697-xhttps://doaj.org/toc/2041-1723Epigenetic regulation is critical for the maintenance of germ cell identity. Here the authors show that H3K9me3-mediated gene silencing is critical for repression of testis-specific transcription in Drosophila female germ cells, indicating H3K9me3 maintains female germ cell sexual identity.Anne E. SmolkoLaura Shapiro-KulnaneHelen K. SalzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne E. Smolko Laura Shapiro-Kulnane Helen K. Salz The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
description	Epigenetic regulation is critical for the maintenance of germ cell identity. Here the authors show that H3K9me3-mediated gene silencing is critical for repression of testis-specific transcription in Drosophila female germ cells, indicating H3K9me3 maintains female germ cell sexual identity.
format	article
author	Anne E. Smolko Laura Shapiro-Kulnane Helen K. Salz
author_facet	Anne E. Smolko Laura Shapiro-Kulnane Helen K. Salz
author_sort	Anne E. Smolko
title	The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
title_short	The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
title_full	The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
title_fullStr	The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
title_full_unstemmed	The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
title_sort	h3k9 methyltransferase setdb1 maintains female identity in drosophila germ cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/74ebcd160d7e4074aa11e9e361e200e3
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The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells

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