Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >...

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Autores principales:	Alvaro N. Barbeira, Scott P. Dickinson, Rodrigo Bonazzola, Jiamao Zheng, Heather E. Wheeler, Jason M. Torres, Eric S. Torstenson, Kaanan P. Shah, Tzintzuni Garcia, Todd L. Edwards, Eli A. Stahl, Laura M. Huckins, GTEx Consortium, Dan L. Nicolae, Nancy J. Cox, Hae Kyung Im
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74f1758878ad410698934b8de48e83e1
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spelling	oai:doaj.org-article:74f1758878ad410698934b8de48e83e12021-12-02T16:49:49ZExploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics10.1038/s41467-018-03621-12041-1723https://doaj.org/article/74f1758878ad410698934b8de48e83e12018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03621-1https://doaj.org/toc/2041-1723Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes.Alvaro N. BarbeiraScott P. DickinsonRodrigo BonazzolaJiamao ZhengHeather E. WheelerJason M. TorresEric S. TorstensonKaanan P. ShahTzintzuni GarciaTodd L. EdwardsEli A. StahlLaura M. HuckinsGTEx ConsortiumDan L. NicolaeNancy J. CoxHae Kyung ImNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alvaro N. Barbeira Scott P. Dickinson Rodrigo Bonazzola Jiamao Zheng Heather E. Wheeler Jason M. Torres Eric S. Torstenson Kaanan P. Shah Tzintzuni Garcia Todd L. Edwards Eli A. Stahl Laura M. Huckins GTEx Consortium Dan L. Nicolae Nancy J. Cox Hae Kyung Im Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
description	Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes.
format	article
author	Alvaro N. Barbeira Scott P. Dickinson Rodrigo Bonazzola Jiamao Zheng Heather E. Wheeler Jason M. Torres Eric S. Torstenson Kaanan P. Shah Tzintzuni Garcia Todd L. Edwards Eli A. Stahl Laura M. Huckins GTEx Consortium Dan L. Nicolae Nancy J. Cox Hae Kyung Im
author_facet	Alvaro N. Barbeira Scott P. Dickinson Rodrigo Bonazzola Jiamao Zheng Heather E. Wheeler Jason M. Torres Eric S. Torstenson Kaanan P. Shah Tzintzuni Garcia Todd L. Edwards Eli A. Stahl Laura M. Huckins GTEx Consortium Dan L. Nicolae Nancy J. Cox Hae Kyung Im
author_sort	Alvaro N. Barbeira
title	Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
title_short	Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
title_full	Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
title_fullStr	Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
title_full_unstemmed	Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
title_sort	exploring the phenotypic consequences of tissue specific gene expression variation inferred from gwas summary statistics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/74f1758878ad410698934b8de48e83e1
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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

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