Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.

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Detalles Bibliográficos
Autores principales: Chanyoung Song, Hathaichanok Phuengkham, Young Seob Kim, Van Vuong Dinh, Inho Lee, Il Woo Shin, Hong Sik Shin, Seung Mo Jin, Soong Ho Um, Hyunseung Lee, Kwan Soo Hong, Seon-Mi Jin, Eunji Lee, Tae Heung Kang, Yeong-Min Park, Yong Taik Lim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/74f56ede70494663b8680f81b8197124
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Descripción
Sumario:The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.

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