Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.

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Autores principales:	Chanyoung Song, Hathaichanok Phuengkham, Young Seob Kim, Van Vuong Dinh, Inho Lee, Il Woo Shin, Hong Sik Shin, Seung Mo Jin, Soong Ho Um, Hyunseung Lee, Kwan Soo Hong, Seon-Mi Jin, Eunji Lee, Tae Heung Kang, Yeong-Min Park, Yong Taik Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/74f56ede70494663b8680f81b8197124
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spelling	oai:doaj.org-article:74f56ede70494663b8680f81b81971242021-12-02T17:01:45ZSyringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence10.1038/s41467-019-11730-82041-1723https://doaj.org/article/74f56ede70494663b8680f81b81971242019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11730-8https://doaj.org/toc/2041-1723The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.Chanyoung SongHathaichanok PhuengkhamYoung Seob KimVan Vuong DinhInho LeeIl Woo ShinHong Sik ShinSeung Mo JinSoong Ho UmHyunseung LeeKwan Soo HongSeon-Mi JinEunji LeeTae Heung KangYeong-Min ParkYong Taik LimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chanyoung Song Hathaichanok Phuengkham Young Seob Kim Van Vuong Dinh Inho Lee Il Woo Shin Hong Sik Shin Seung Mo Jin Soong Ho Um Hyunseung Lee Kwan Soo Hong Seon-Mi Jin Eunji Lee Tae Heung Kang Yeong-Min Park Yong Taik Lim Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
description	The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.
format	article
author	Chanyoung Song Hathaichanok Phuengkham Young Seob Kim Van Vuong Dinh Inho Lee Il Woo Shin Hong Sik Shin Seung Mo Jin Soong Ho Um Hyunseung Lee Kwan Soo Hong Seon-Mi Jin Eunji Lee Tae Heung Kang Yeong-Min Park Yong Taik Lim
author_facet	Chanyoung Song Hathaichanok Phuengkham Young Seob Kim Van Vuong Dinh Inho Lee Il Woo Shin Hong Sik Shin Seung Mo Jin Soong Ho Um Hyunseung Lee Kwan Soo Hong Seon-Mi Jin Eunji Lee Tae Heung Kang Yeong-Min Park Yong Taik Lim
author_sort	Chanyoung Song
title	Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
title_short	Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
title_full	Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
title_fullStr	Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
title_full_unstemmed	Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
title_sort	syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/74f56ede70494663b8680f81b8197124
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Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

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